VSX2

Across TCGA patient cohorts, VSX2 mutation is significantly associated with the RNA expression of many other genes, with 942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSX2-associated genes across cancer lineages are AP3S2, CUEDC1, and STSP1. Each is linked with VSX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSX2-to-partner and partner-to-VSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP3S2 grouped by VSX2-low versus VSX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX2→partner) and Y-score (partner→VSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP3S2 →	+0.381	+2.700	.003	.006	3	2
UCEC	CUEDC1 →	+0.938	+3.480	<.001	.002	3	2
SKCM	STSP1 →	+0.023	+3.943	<.001	.002	3	2
SKCM	EEF1A1P39 →	+0.112	+2.885	.002	.008	3	2
COAD	RPS12P15 →	+0.179	+4.693	<.001	<.001	3	2
SKCM	IL9 →	+0.178	+4.037	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 942 associations by consensus.

AP3S2 by VSX2 expression — UCEC

Explore this box plot interactively →