VSX2

Across TCGA patient cohorts, VSX2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSX2-associated genes across cancer lineages are MAPK_pT202_Y204, Rab11, and Rad50. Each is linked with VSX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSX2-to-partner and partner-to-VSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by VSX2-low versus VSX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX2→partner) and Y-score (partner→VSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	+0.612	+2.820	.012	.035	3	1
UCEC	Rab11 →	-0.162	-3.321	.033	.010	3	1
UCEC	Rad50 →	-0.330	-3.321	.009	.010	3	1
UCEC	Rb_pS807_S811 →	+0.466	+3.321	.028	.010	3	1
UCEC	Src_pY416 →	+0.270	+2.183	.032	.035	3	1
UCEC	CDK1_pY15 →	+0.228	+3.343	.036	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MAPK_pT202_Y204 by VSX2 expression — UCEC

Explore this box plot interactively →