VSX2

Across TCGA cell cohorts, VSX2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible VSX2-associated genes across cancer lineages are FERD3L, PRAMEF10, and PRAMEF17. Each is linked with VSX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSX2-to-partner and partner-to-VSX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FERD3L grouped by VSX2-low versus VSX2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX2→partner) and Y-score (partner→VSX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FERD3L →	+1.413	+4.070	<.001	.003	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF15 →	+0.382	+3.817	<.001	.004	3	1
LUNG_SCLC	INS →	+0.502	+4.169	<.001	.001	3	1
LUNG_SCLC	OR13C5 →	+0.029	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FERD3L by VSX2 expression — LUNG_SCLC

Explore this box plot interactively →