VSX1

Across TCGA patient cohorts, VSX1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSX1-associated genes across cancer lineages are CD8+ Tem, NK cells, and CD4+ Tcm. Each is linked with VSX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSX1-to-partner and partner-to-VSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by VSX1-low versus VSX1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX1→partner) and Y-score (partner→VSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	CD8+ Tem →	+0.018	+5.285	<.001	.049	3	1
ESCA	NK cells →	+0.002	+5.709	.002	.037	3	1
HNSC	CD4+ Tcm →	+0.013	+5.468	<.001	.043	3	1
UCEC	Epithelial cells →	-0.077	-2.989	.049	.035	3	1
UCEC	Endothelial cells →	-0.045	-3.127	.030	.020	1	1
UCEC	MEP →	+0.053	+3.180	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ Tem by VSX1 expression — ESCA

Explore this box plot interactively →