VSX1

Across TCGA cell cohorts, VSX1 mutation is significantly associated with the mutation status of many other genes, with 1,313 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VSX1-associated genes across cancer lineages are HELB, PAPSS1, and CYP7B1. Each is linked with VSX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VSX1-to-partner and partner-to-VSX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELB grouped by VSX1-low versus VSX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSX1→partner) and Y-score (partner→VSX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HELB →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	PAPSS1 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	CYP7B1 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	ZNF546 →	+4.309	+4.560	.007	.007	1	3
LUNG_NSCLC_LUAD	IFT80 →	+2.981	+3.266	.009	.009	1	2
BLOOD_Leukemia	SUCO →	+3.894	+5.247	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,313 associations by consensus.

HELB by VSX1 expression — BLOOD_Leukemia

Explore this box plot interactively →