VSTM4

Across TCGA pan-cancer cohorts, VSTM4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VSTM4 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher VSTM4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VSTM4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

STAD, SKCM, and HNSC are the cancer types where VSTM4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	IV	0.001	0.544	<.001	15	view →
SKCM	DFS	Median	III,IV	0.921	0.554	.010	11	view →
HNSC	OS	Median	All	0.191	0.710	.021	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	All	0.517	0.786	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VSTM4–STAD (OS)

Open the STAD breakdown →