VSTM4

Across TCGA pan-cancer cohorts, VSTM4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VSTM4 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VSTM4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VSTM4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, GBM, and LUAD are the cancer types where VSTM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.700	0.946	<.001	12	view →
GBM	DFS	Median	All	0.767	0.249	.004	6	view →
LUAD	OS	Median	II,III,IV	0.430	0.779	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VSTM4–LSCC (OS)

Open the LSCC breakdown →