VSTM4

Across TCGA patient cohorts, VSTM4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,461 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VSTM4-associated genes across cancer lineages are SRPX, PDLIM2, and CNOT1. Each is linked with VSTM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSTM4-to-partner and partner-to-VSTM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VSTM4 versus SRPX in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM4→partner) and Y-score (partner→VSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRPX →	+1.056	+0.365	<.001	<.001	3	2
LUAD	PDLIM2 →	+0.463	+0.391	<.001	<.001	3	2
LUAD	CNOT1 →	-0.515	-0.565	.004	.001	3	2
LSCC	PODN →	+0.672	+0.333	<.001	.001	3	2
LSCC	MRPL11 →	-0.604	-0.327	<.001	.004	3	2
GBM	BTF3L4P3 →	+0.223	+0.444	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,461 associations by consensus.

VSTM4 vs SRPX — LSCC

Explore this scatter interactively →