VSTM4

Across TCGA patient cohorts, VSTM4 mutation is significantly associated with the RNA expression of many other genes, with 2,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSTM4-associated genes across cancer lineages are SERBP1P2, RPL32P19, and RNU6-649P. Each is linked with VSTM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both VSTM4-to-partner and partner-to-VSTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERBP1P2 grouped by VSTM4-low versus VSTM4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM4→partner) and Y-score (partner→VSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SERBP1P2 →	+0.294	+4.621	<.001	.004	3	3
COAD	RPL32P19 →	+0.144	+2.847	<.001	.004	3	3
STAD	RNU6-649P →	+0.595	+3.391	<.001	.003	3	3
HNSC	DUXAP11 →	+0.110	+4.221	<.001	.008	3	3
UCEC	SKA1 →	+0.702	+3.024	<.001	<.001	3	3
SKCM	PPP2R2D →	+0.353	+1.868	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,271 associations by consensus.

SERBP1P2 by VSTM4 expression — LUSC

Explore this box plot interactively →