VSTM4

Across TCGA patient cohorts, VSTM4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSTM4-associated genes across cancer lineages are Cyclin-B1, PCNA, and Cyclin-E1. Each is linked with VSTM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both VSTM4-to-partner and partner-to-VSTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by VSTM4-low versus VSTM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM4→partner) and Y-score (partner→VSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.747	+3.584	<.001	.002	3	4
SKCM	PCNA →	+0.247	+3.584	<.001	.002	3	3
COAD	Cyclin-E1 →	+0.452	+2.820	<.001	.035	3	3
UCEC	EGFR_pY1068 →	-0.280	-2.087	.003	.005	3	2
UCEC	FoxM1 →	+0.249	+2.331	.012	.019	3	2
UCEC	PDCD4 →	-0.603	-1.990	<.001	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-B1 by VSTM4 expression — UCEC

Explore this box plot interactively →