VSTM4

Across TCGA cell cohorts, VSTM4 mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VSTM4-associated genes across cancer lineages are TNRC6B, SGSM3, and L3MBTL2. Each is linked with VSTM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSTM4-to-partner and partner-to-VSTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6B grouped by VSTM4-low versus VSTM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSTM4→partner) and Y-score (partner→VSTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+0.933	+3.502	<.001	.001	3	1
LARGE_INTESTINE	SGSM3 →	+0.782	+3.137	<.001	.007	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.738	+3.502	<.001	.001	3	1
LARGE_INTESTINE	PLTP →	-1.931	-3.321	.004	.003	3	1
LARGE_INTESTINE	CTSZ →	-1.018	-3.416	.003	.002	3	1
LARGE_INTESTINE	USP14 →	+0.631	+3.237	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

TNRC6B by VSTM4 expression — LARGE_INTESTINE

Explore this box plot interactively →