Across TCGA pan-cancer cohorts, VSTM2B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VSTM2B data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VSTM2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VSTM2B expression acts as an unfavorable survival marker.

UCEC, CESC, and ESCA are the cancer types where VSTM2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
CESC	DFS	Median	II,III,IV	0.173	0.705	.028	6	view →
ESCA	DFS	Median	All	0.171	0.506	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: VSTM2B tumor-vs-normal RNA expression · all VSTM2B data types