Across TCGA pan-cancer cohorts, VSTM2B RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of VSTM2B’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where VSTM2B RNA is repressed in tumor relative to normal tissue. In most cancer types VSTM2B is over-expressed in tumor, although a few such as STAD and KIRP show the opposite, repressed pattern.

STAD, KIRP, and LIHC are the cancer types where VSTM2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VSTM2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.184	.006	4	view →
KIRP	All	All	−0.044	.008	4	view →
LIHC	All	All	+0.004	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: VSTM2B RNA expression & survival · all VSTM2B data types