VRK2

Across TCGA patient cohorts, VRK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,940 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible VRK2-associated proteins across cancer lineages are SPAST, PSME4, and MCM3. Each is linked with VRK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VRK2 versus SPAST in LSCC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPAST →	+0.353	+0.379	<.001	<.001	3	7
BRCA	PSME4 →	+0.312	+0.433	.002	.006	3	6
LSCC	MCM3 →	+0.706	+0.571	<.001	<.001	3	6
LSCC	MCM5 →	+0.679	+0.575	<.001	<.001	3	6
LSCC	MCM7 →	+0.666	+0.646	<.001	<.001	3	6
LSCC	RFC2 →	+0.506	+0.810	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,940 associations by consensus.

VRK2 vs SPAST — LSCC

Explore this scatter interactively →