VRK1

Across TCGA pan-cancer cohorts, VRK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VRK1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VRK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VRK1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where VRK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.863	0.506	.002	41	view →
HNSC	DFS	Median	All	0.264	0.886	.002	34	view →
LUAD	DFS	Median	III,IV	0.901	0.611	.035	6	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
CCRCC	DFS	Tertile	All	0.651	1.000	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VRK1–LSCC (DFS)

Open the LSCC breakdown →