VRK1

Across TCGA pan-cancer cohorts, VRK1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VRK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VRK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VRK1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where VRK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VRK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.112	<.001	12	view →
BLCA	Male	III,IV	+1.390	<.001	11	view →
LIHC	Female	II,III,IV	+1.241	<.001	9	view →
STAD	Female	All	+1.148	<.001	9	view →
LUSC	Female	II,III,IV	+1.624	<.001	8	view →
COAD	All	II,III,IV	+0.755	<.001	7	view →
THCA	All	All	−0.290	<.001	7	view →
UCEC	All	II,III,IV	+1.120	.004	6	view →
LUAD	Male	All	+0.798	<.001	6	view →
BRCA	All	II,III,IV	+0.492	<.001	6	view →
KIRP	All	II,III,IV	+0.470	.016	6	view →
CHOL	Male	All	+2.070	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VRK1–HNSC

Open the HNSC breakdown →