VRK1

Across TCGA patient cohorts, VRK1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,776 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VRK1-associated genes across cancer lineages are CDCA4, MCM5, and CDKN3. Each is linked with VRK1 in more than 9 cancer types. Because this analysis shows association rather than direction, both VRK1-to-partner and partner-to-VRK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VRK1 versus CDCA4 in BRCA, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK1→partner) and Y-score (partner→VRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA4 →	+0.807	+0.422	<.001	<.001	3	10
HNSC	MCM5 →	+0.996	+0.314	<.001	.001	3	9
UCEC	CDKN3 →	+1.050	+0.371	<.001	<.001	3	9
LUAD	GINS1 →	+1.174	+0.460	<.001	<.001	3	9
LSCC	CENPI →	+1.102	+0.649	<.001	<.001	3	9
OV	MCM4 →	+0.904	+0.432	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,776 associations by consensus.

VRK1 vs CDCA4 — BRCA

Explore this scatter interactively →