VRK1

Across TCGA patient cohorts, VRK1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VRK1-associated genes across cancer lineages are FASN, MEK1, and ACC_pS79. Each is linked with VRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK1-to-partner and partner-to-VRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by VRK1-low versus VRK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK1→partner) and Y-score (partner→VRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.354	+1.700	.019	.042	3	2
UCEC	MEK1 →	+0.512	+3.906	<.001	<.001	3	2
UCEC	ACC_pS79 →	+0.274	+1.884	.039	.030	3	1
UCEC	MSH2 →	-0.216	-1.848	.014	.049	3	1
UCEC	mTOR_pS2448 →	-0.142	-1.861	.013	.049	3	1
UCEC	p27_pT198 →	+0.110	+1.678	.007	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FASN by VRK1 expression — UCEC

Explore this box plot interactively →