VRK1

Across TCGA cell cohorts, VRK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,243 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible VRK1-associated GO terms across cancer lineages are Kinetochore assembly, DNA-templated DNA replication, and DNA replication initiation. Each is linked with VRK1 in more than 19 cancer types. Because this analysis shows association rather than direction, both VRK1-to-partner and partner-to-VRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Kinetochore assembly grouped by VRK1-low versus VRK1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK1→partner) and Y-score (partner→VRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Kinetochore assembly →	+0.186	+1.525	.001	<.001	3	20
LUNG_NSCLC_LUSC	DNA-templated DNA replication →	+0.128	+1.082	<.001	.002	3	20
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.239	+1.155	<.001	<.001	3	20
SKIN	Kinetochore organization →	+0.172	+0.894	<.001	<.001	3	20
PANCREAS	DNA replication →	+0.115	+1.026	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Recombinational repair →	+0.097	+1.695	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,243 associations by consensus.

Kinetochore assembly by VRK1 expression — BLOOD_Myeloma

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