VPS54

Across TCGA pan-cancer cohorts, VPS54 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated VPS54 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VPS54 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS54 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and OV are the cancer types where VPS54 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.955	0.617	.007	34	view →
COAD	OS	Median	II,III,IV	0.182	0.609	<.001	32	view →
OV	DFS	Median	II,III,IV	0.215	0.541	.027	18	view →
SKCM	OS	Median	All	0.287	0.788	<.001	18	view →
LGG	OS	Median	All	0.208	0.896	<.001	12	view →
HNSC	DFS	Median	All	0.098	0.710	<.001	12	view →
GBM	OS	Median	All	0.062	0.416	.001	6	view →
PRAD	DFS	Median	All	0.072	0.935	<.001	6	view →
BLCA	DFS	Median	III,IV	0.160	0.551	.001	6	view →
LIHC	OS	Median	All	0.275	0.691	.024	6	view →
BRCA	OS	Median	All	0.194	0.580	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

VPS54–UCEC (DFS)

Open the UCEC breakdown →