VPS54

Across TCGA pan-cancer cohorts, VPS54 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VPS54’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where VPS54 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS54 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and BLCA are the cancer types where VPS54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.185	<.001	9	view →
THCA	Male	III,IV	−0.925	<.001	9	view →
BLCA	All	All	+0.538	<.001	9	view →
COAD	Male	All	+0.474	<.001	6	view →
CHOL	All	All	+2.682	<.001	5	view →
KICH	Female	All	−1.139	<.001	5	view →
STAD	All	II,III,IV	+0.540	.006	5	view →
HNSC	All	III,IV	+0.451	.013	5	view →
LUAD	Male	All	+0.442	.001	4	view →
READ	All	III,IV	+0.724	.031	3	view →
KIRC	All	All	+0.192	.016	3	view →
PRAD	All	All	+0.395	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VPS54–LIHC

Open the LIHC breakdown →