VPS54

Across TCGA pan-cancer cohorts, VPS54 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated VPS54 data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VPS54 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS54 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC and CCRCC are the cancer types where VPS54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.720	0.855	.023	8	view →
CCRCC	OS	Quartile	All	1.000	0.885	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

VPS54–LSCC (DFS)

Open the LSCC breakdown →