VPS54

Across TCGA patient cohorts, VPS54 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS54-associated genes across cancer lineages are ASNS, p21, and PR. Each is linked with VPS54 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS54-to-partner and partner-to-VPS54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VPS54-low versus VPS54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS54→partner) and Y-score (partner→VPS54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.398	+2.906	.002	.001	3	3
UCEC	p21 →	+0.142	+3.584	.045	.002	3	2
UCEC	PR →	-0.204	-2.000	.027	.030	3	2
UCEC	Tuberin_pT1462 →	+0.193	+1.495	.023	.034	3	2
UCEC	ATM →	-0.552	-2.247	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.073	-2.432	.047	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by VPS54 expression — UCEC

Explore this box plot interactively →