VPS54

Across TCGA cell cohorts, VPS54 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,286 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible VPS54-associated GO terms across cancer lineages are Motor neuron apoptotic process, Skeletal muscle tissue growth, and Golgi to vacuole transport. Each is linked with VPS54 in more than 13 cancer types. Because this analysis shows association rather than direction, both VPS54-to-partner and partner-to-VPS54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Motor neuron apoptotic process grouped by VPS54-low versus VPS54-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS54→partner) and Y-score (partner→VPS54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Motor neuron apoptotic process →	+0.598	+0.552	.006	<.001	3	14
SOFT_TISSUE	Skeletal muscle tissue growth →	+0.703	+0.549	.003	<.001	3	12
LUNG_SCLC	Golgi to vacuole transport →	+0.137	+0.588	.001	.002	3	12
LIVER	Negative regulation of motor neuron apoptotic process →	+0.277	+1.161	<.001	.001	3	11
LUNG_NSCLC_LUSC	Regulation of female receptivity →	+1.404	+0.878	.002	.001	2	12
LIVER	Regulation of motor neuron apoptotic process →	+0.336	+1.395	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,286 associations by consensus.

Motor neuron apoptotic process by VPS54 expression — BREAST

Explore this box plot interactively →