VPS54

Across TCGA cell cohorts, VPS54 mutation is significantly associated with the drug of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS54-associated genes across cancer lineages are kb NB 142-70, PRT062607, and CDK9_5576. Each is linked with VPS54 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS54-to-partner and partner-to-VPS54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, kb NB 142-70 grouped by VPS54-low versus VPS54-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS54→partner) and Y-score (partner→VPS54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	kb NB 142-70 →	+0.503	+2.652	.033	.045	3	1
LARGE_INTESTINE	PRT062607 →	+0.583	+2.769	.020	.040	2	1
LARGE_INTESTINE	CDK9_5576 →	+0.546	+2.649	.036	.046	2	1
LARGE_INTESTINE	Quizartinib →	+0.400	+2.652	.012	.045	1	2
LARGE_INTESTINE	Entospletinib →	+0.378	+2.646	.049	.047	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.680	+2.906	.012	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

kb NB 142-70 by VPS54 expression — LARGE_INTESTINE

Explore this box plot interactively →