VPS53

Across TCGA pan-cancer cohorts, VPS53 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VPS53 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VPS53 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS53 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where VPS53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.881	0.584	.002	55	view →
LUAD	OS	Median	II,III,IV	1.000	0.867	.006	24	view →
CCRCC	DFS	Tertile	II,III,IV	0.983	0.737	.014	10	view →
GBM	OS	Tertile	All	0.599	0.965	.023	3	view →
UCEC	DFS	Median	All	0.938	0.794	.019	2	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →
LSCC	DFS	Median	III,IV	0.684	0.917	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VPS53–PDAC (DFS)

Open the PDAC breakdown →