VPS53

Across TCGA cell cohorts, VPS53 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,035 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS53-associated GO terms across cancer lineages are Cytosolic transport, Vesicle-mediated cholesterol transport, and Vesicle-mediated transport to the plasma membrane. Each is linked with VPS53 in more than 15 cancer types. Because this analysis shows association rather than direction, both VPS53-to-partner and partner-to-VPS53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by VPS53-low versus VPS53-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS53→partner) and Y-score (partner→VPS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.079	+1.068	<.001	<.001	3	16
BONE	Vesicle-mediated cholesterol transport →	+0.146	+1.080	.001	<.001	3	16
CNS	Vesicle-mediated transport to the plasma membrane →	+0.075	+1.030	<.001	<.001	3	16
LARGE_INTESTINE	Positive regulation of mitotic cytokinesis →	+0.154	+1.074	<.001	<.001	3	16
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.079	+0.924	<.001	<.001	3	15
OESOPHAGUS	Nucleic acid transport →	+0.139	+1.551	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,035 associations by consensus.

Cytosolic transport by VPS53 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →