VPS53

Across TCGA cell cohorts, VPS53 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS53-associated genes across cancer lineages are C20orf173, OR10G7, and OR5W2. Each is linked with VPS53 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS53-to-partner and partner-to-VPS53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf173 grouped by VPS53-low versus VPS53-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS53→partner) and Y-score (partner→VPS53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C20orf173 →	+0.070	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR10G7 →	+0.012	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	OR5W2 →	+0.011	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	PRSS45P →	+0.221	+4.321	<.001	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.013	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	GUCA2A →	+0.032	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C20orf173 by VPS53 expression — BLOOD_Lymphoma

Explore this box plot interactively →