Across TCGA patient cohorts, VPS52 mutation is significantly associated with the RNA expression of many other genes, with 2,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS52-associated genes across cancer lineages are SPATA31A5, TMEM225, and OR6V1. Each is linked with VPS52 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS52-to-partner and partner-to-VPS52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS52→partner) and Y-score (partner→VPS52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPATA31A5 →	+0.006	+4.179	<.001	.001	3	2
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
READ	OR6V1 →	+0.150	+5.653	<.001	.003	3	2
SKCM	GTF3C6P1 →	+0.056	+3.560	<.001	.002	3	2
SKCM	CHCHD2P1 →	+0.084	+3.906	.002	.001	3	2
SKCM	BUB3P1 →	+0.039	+3.182	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,315 associations by consensus.

Exploration

VPS52 survival (RNA) · tumor vs normal (RNA) · all VPS52 data types