VPS51

Across TCGA pan-cancer cohorts, VPS51 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VPS51 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher VPS51 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS51 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where VPS51 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.429	0.929	.003	17	view →
CCRCC	DFS	Median	All	0.972	0.863	.012	14	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	14	view →
OV	DFS	Median	All	1.000	0.870	.045	4	view →
LUAD	OS	Tertile	All	1.000	0.880	.016	4	view →
HNSC	DFS	Median	IV	0.683	0.917	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VPS51–LSCC (DFS)

Open the LSCC breakdown →