VPS51

Across TCGA pan-cancer cohorts, VPS51 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VPS51’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where VPS51 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS51 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

LIHC, THCA, and BLCA are the cancer types where VPS51 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS51 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.772	<.001	9	view →
THCA	Male	III,IV	−0.547	<.001	9	view →
BLCA	Male	IV	−0.684	<.001	8	view →
KIRP	Male	All	−0.880	<.001	7	view →
UCEC	All	All	−0.931	<.001	6	view →
BRCA	Female	All	−0.681	<.001	6	view →
LUAD	Female	All	−0.367	<.001	6	view →
COAD	All	All	+0.315	.006	4	view →
CHOL	All	All	+1.196	<.001	3	view →
STAD	Male	II,III,IV	+0.554	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VPS51–LIHC

Open the LIHC breakdown →