VPS51

Across TCGA cell cohorts, VPS51 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,254 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible VPS51-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Positive regulation of attachment of mitotic spindle microtubules to kinetochore, and Regulation of attachment of mitotic spindle microtubules to kinetochore. Each is linked with VPS51 in more than 13 cancer types. Because this analysis shows association rather than direction, both VPS51-to-partner and partner-to-VPS51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by VPS51-low versus VPS51-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS51→partner) and Y-score (partner→VPS51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.169	+0.909	<.001	<.001	3	14
URINARY_TRACT	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.185	+0.854	<.001	<.001	3	14
PANCREAS	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.150	+0.838	<.001	.001	3	13
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.146	+0.763	.007	.003	3	11
BONE	Pre-mRNA catabolic process →	+0.229	+0.924	.001	.003	3	11
OESOPHAGUS	Regulation of cell fate specification →	+0.136	+1.128	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,254 associations by consensus.

Transcription pausing by RNA polymerase II by VPS51 expression — BONE

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