VPS51

Across TCGA cell cohorts, VPS51 mutation is significantly associated with the RNA expression of many other genes, with 1,064 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS51-associated genes across cancer lineages are HES3, LIN54, and SLC35G3. Each is linked with VPS51 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS51-to-partner and partner-to-VPS51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HES3 grouped by VPS51-low versus VPS51-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS51→partner) and Y-score (partner→VPS51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	2
LARGE_INTESTINE	LIN54 →	+0.538	+1.850	.006	.006	3	2
PANCREAS	SLC35G3 →	+0.007	+4.786	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRAMEF9 →	+0.012	+5.228	<.001	.005	3	1
BREAST	OR7A10 →	+0.008	+4.196	<.001	.006	3	1
BREAST	GPR25 →	+0.275	+4.025	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,064 associations by consensus.

HES3 by VPS51 expression — CNS

Explore this box plot interactively →