VPS4A

Across TCGA patient cohorts, VPS4A mutation is significantly associated with the RNA expression of many other genes, with 1,437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS4A-associated genes across cancer lineages are RN7SL447P, RN7SL415P, and SCARNA21B. Each is linked with VPS4A in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS4A-to-partner and partner-to-VPS4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL447P grouped by VPS4A-low versus VPS4A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4A→partner) and Y-score (partner→VPS4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL447P →	+0.141	+5.497	.002	.004	3	3
CESC	RN7SL415P →	+0.143	+5.812	<.001	.003	3	2
READ	SCARNA21B →	+0.384	+5.039	<.001	.008	3	2
READ	RN7SL470P →	+0.168	+5.653	<.001	.003	3	2
CESC	HMGB1P25 →	+0.067	+5.201	<.001	.007	3	2
UCEC	RAET1K →	+0.437	+3.491	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,437 associations by consensus.

RN7SL447P by VPS4A expression — BLCA

Explore this box plot interactively →