VPS41

Across TCGA pan-cancer cohorts, VPS41 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS41 data layer compared with 21 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher VPS41 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS41 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

ESCA, HNSC, and STAD are the cancer types where VPS41 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.130	0.539	<.001	24	view →
HNSC	DFS	Median	IV	1.000	0.313	.022	13	view →
STAD	DFS	Median	All	1.000	0.613	.018	8	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
SCLC	DFS	Median	All	1.000	0.219	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS41–ESCA (DFS)

Open the ESCA breakdown →