VPS41

Across TCGA pan-cancer cohorts, VPS41 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VPS41 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS41 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS41 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where VPS41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.337	0.653	.009	20	view →
CCRCC	OS	Median	All	0.741	1.000	.027	8	view →
HNSC	OS	Quartile	IV	0.552	0.871	.016	7	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
LSCC	DFS	Median	All	0.903	0.694	.018	4	view →
PDAC	DFS	Median	IV	0.959	0.409	.049	3	view →
GBM	OS	Tertile	All	0.928	0.754	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VPS41–LUAD (DFS)

Open the LUAD breakdown →