VPS41

Across TCGA patient cohorts, VPS41 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS41-associated genes across cancer lineages are FoxM1, Notch1, and p62 Lck ligand. Each is linked with VPS41 in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS41-to-partner and partner-to-VPS41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by VPS41-low versus VPS41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS41→partner) and Y-score (partner→VPS41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.284	+2.000	.005	.010	3	3
UCEC	Notch1 →	+0.196	+2.502	<.001	.002	3	3
SKCM	p62 Lck ligand →	+0.608	+2.820	.005	.035	2	4
UCEC	4E-BP1 →	+0.338	+2.321	.001	.033	3	3
UCEC	Cyclin-B1 →	+0.801	+3.459	<.001	.005	3	3
UCEC	p27_pT198 →	+0.106	+2.502	.011	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by VPS41 expression — UCEC

Explore this box plot interactively →