VPS41

Across TCGA cell cohorts, VPS41 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,138 significant associations in total. CNS shows the largest number of these associations.

The most reproducible VPS41-associated GO terms across cancer lineages are Macroautophagy, Process utilizing autophagic mechanism, and Autophagy. Each is linked with VPS41 in more than 18 cancer types. Because this analysis shows association rather than direction, both VPS41-to-partner and partner-to-VPS41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by VPS41-low versus VPS41-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS41→partner) and Y-score (partner→VPS41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.072	+1.106	<.001	<.001	3	19
KIDNEY	Process utilizing autophagic mechanism →	+0.070	+1.028	.002	.004	3	18
KIDNEY	Autophagy →	+0.070	+1.028	.002	.004	3	18
CNS	Protein targeting to vacuole →	+0.076	+0.823	<.001	<.001	3	18
SKIN	Positive regulation of isotype switching to IgG isotypes →	+0.120	+1.102	<.001	<.001	3	17
KIDNEY	Vacuolar transport →	+0.069	+1.282	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

Macroautophagy by VPS41 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →