VPS37D

Across TCGA cell cohorts, VPS37D mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS37D-associated genes across cancer lineages are GJD2, KRTAP10-6, and KRTAP10-9. Each is linked with VPS37D in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37D-to-partner and partner-to-VPS37D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by VPS37D-low versus VPS37D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37D→partner) and Y-score (partner→VPS37D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	KRTAP10-6 →	+0.044	+4.347	<.001	.001	3	1
LARGE_INTESTINE	KRTAP10-9 →	+0.067	+3.930	<.001	.003	3	1
LARGE_INTESTINE	KRTAP12-2 →	+0.054	+3.930	<.001	.003	3	1
LARGE_INTESTINE	KRTAP10-5 →	+0.020	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GJD2 by VPS37D expression — LARGE_INTESTINE

Explore this box plot interactively →