VPS37B

Across TCGA patient cohorts, VPS37B mutation is significantly associated with the RNA expression of many other genes, with 1,756 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS37B-associated genes across cancer lineages are RNU6-90P, LINC01744, and PMS2P11. Each is linked with VPS37B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37B-to-partner and partner-to-VPS37B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-90P grouped by VPS37B-low versus VPS37B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37B→partner) and Y-score (partner→VPS37B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-90P →	+0.459	+2.289	.001	.001	3	2
SKCM	LINC01744 →	+0.026	+4.208	<.001	.003	3	2
SKCM	PMS2P11 →	+0.072	+3.661	.004	.009	3	2
COAD	RNU6-378P →	+0.595	+3.588	<.001	.007	3	2
COAD	DDX6P1 →	+0.081	+4.452	<.001	<.001	3	2
UCEC	RNY1P1 →	+0.184	+3.220	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,756 associations by consensus.

RNU6-90P by VPS37B expression — UCEC

Explore this box plot interactively →