VPS37A

Across TCGA patient cohorts, VPS37A mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS37A-associated genes across cancer lineages are CD8+ naive T-cells, Endothelial cells, and lymphatic Endothelial cells. Each is linked with VPS37A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS37A-to-partner and partner-to-VPS37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by VPS37A-low versus VPS37A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37A→partner) and Y-score (partner→VPS37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.038	+3.186	.004	.010	3	1
UCEC	Endothelial cells →	-0.040	-2.279	.037	.036	3	1
UCEC	lymphatic Endothelial cells →	-0.026	-3.405	.031	.005	3	1
UCEC	mv Endothelial cells →	-0.027	-3.000	.025	.036	3	1
UCEC	Erythrocytes →	+0.035	+2.879	.005	.033	2	1
UCEC	Plasma cells →	-0.024	-3.416	.024	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ naive T-cells by VPS37A expression — UCEC

Explore this box plot interactively →