VPS37A

Across TCGA pan-cancer cohorts, VPS37A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VPS37A data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VPS37A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS37A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

MESO, HNSC, and KICH are the cancer types where VPS37A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	II,III,IV	0.232	0.501	.001	81	view →
HNSC	DFS	Quartile	IV	0.650	0.421	<.001	47	view →
KICH	DFS	Quartile	All	0.499	1.000	<.001	44	view →
LIHC	OS	Quartile	All	0.658	0.835	.001	37	view →
BLCA	DFS	Tertile	All	0.263	0.658	<.001	35	view →
LAML	DFS	Median	All	0.558	0.373	.006	34	view →
STAD	DFS	Tertile	IV	0.152	0.709	.001	28	view →
KIRC	DFS	Quartile	All	0.721	0.454	.006	26	view →
SKCM	OS	Quartile	All	0.538	0.298	.003	21	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
DLBC	DFS	Median	All	0.629	1.000	.017	16	view →
PAAD	OS	Tertile	II,III,IV	0.529	0.272	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VPS37A–MESO (DFS)

Open the MESO breakdown →