VPS37A

Across TCGA cell cohorts, VPS37A protein abundance is significantly associated with the go_rna of many other GO terms, with 1,080 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS37A-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Regulation of intracellular pH, and Negative regulation of heterochromatin organization. Each is linked with VPS37A in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS37A-to-partner and partner-to-VPS37A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by VPS37A-low versus VPS37A-high in LUNG_SCLC.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS37A→partner) and Y-score (partner→VPS37A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of cell cycle process →	-0.058	-1.920	.007	.003	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular pH →	-0.097	-1.989	<.001	.006	3	3
LUNG_NSCLC_LUAD	Negative regulation of heterochromatin organization →	-0.106	-1.338	<.001	.001	3	3
LUNG_NSCLC_LUAD	Negative regulation of epithelial cell apoptotic process →	-0.217	-1.738	.002	.009	3	3
LUNG_NSCLC_LUAD	Negative regulation of heterochromatin formation →	-0.106	-1.338	<.001	.001	3	3
LARGE_INTESTINE	Positive regulation of extracellular matrix assembly →	+0.225	+1.147	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

Negative regulation of cell cycle process by VPS37A expression — LUNG_SCLC

Explore this box plot interactively →