VPS36

Across TCGA patient cohorts, VPS36 mutation is significantly associated with the RNA expression of many other genes, with 1,816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS36-associated genes across cancer lineages are MLLT10P2, OR4K17, and RNU6-805P. Each is linked with VPS36 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS36-to-partner and partner-to-VPS36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT10P2 grouped by VPS36-low versus VPS36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS36→partner) and Y-score (partner→VPS36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLLT10P2 →	+0.180	+2.657	<.001	.002	3	2
UCEC	OR4K17 →	+0.033	+2.833	.003	.009	3	2
SKCM	RNU6-805P →	+0.265	+4.771	<.001	.006	3	1
SKCM	MIR491 →	+0.357	+4.241	.008	.008	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	RNU1-48P →	+0.304	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,816 associations by consensus.

MLLT10P2 by VPS36 expression — UCEC

Explore this box plot interactively →