VPS35

Across TCGA pan-cancer cohorts, VPS35 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated VPS35 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS35 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS35 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where VPS35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.240	0.795	<.001	14	view →
CCRCC	DFS	Quartile	All	0.509	0.837	.008	10	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	OS	Median	II,III,IV	0.811	0.631	.025	4	view →
LSCC	DFS	Median	II,III,IV	0.965	0.876	.039	2	view →
GBM	DFS	Median	All	0.829	0.668	.009	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

VPS35–LUAD (DFS)

Open the LUAD breakdown →