VPS35

Across TCGA pan-cancer cohorts, VPS35 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VPS35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where VPS35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VPS35 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRP, HNSC, and LIHC are the cancer types where VPS35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	+1.174	<.001	11	view →
HNSC	All	III,IV	+0.567	<.001	10	view →
LIHC	Female	II,III,IV	+0.975	<.001	9	view →
LUAD	Male	All	+0.616	<.001	6	view →
BRCA	All	II,III,IV	+0.270	.002	6	view →
CHOL	Male	All	+2.188	<.001	5	view →
KICH	All	All	−0.619	<.001	5	view →
STAD	Male	II,III,IV	+0.478	.004	5	view →
BLCA	All	All	+0.452	.012	5	view →
LUSC	All	All	+0.378	<.001	5	view →
KIRC	All	All	+0.276	<.001	5	view →
COAD	Male	All	+0.464	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VPS35–KIRP

Open the KIRP breakdown →