VPS35

Across TCGA patient cohorts, VPS35 protein abundance is significantly associated with the RNA expression of many other genes, with 9,291 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VPS35-associated genes across cancer lineages are SEC24C, DNAJA2, and HPS1. Each is linked with VPS35 in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS35-to-partner and partner-to-VPS35 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS35 versus SEC24C in UCEC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS35→partner) and Y-score (partner→VPS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC24C →	+0.522	+0.121	<.001	.003	3	6
LSCC	DNAJA2 →	+0.517	+0.159	<.001	<.001	3	5
UCEC	HPS1 →	+0.748	+0.142	.001	.003	3	5
UCEC	ANXA7 →	+0.525	+0.113	<.001	.004	3	5
UCEC	LDB1 →	+0.571	+0.144	.001	<.001	3	5
LSCC	AKTIP →	+0.394	+0.130	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,291 associations by consensus.

VPS35 vs SEC24C — UCEC

Explore this scatter interactively →