VPS35

Across TCGA cell cohorts, VPS35 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,260 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible VPS35-associated GO terms across cancer lineages are Positive regulation of dopamine metabolic process, Regulation of locomotion involved in locomotory behavior, and Positive regulation of dopamine receptor signaling pathway. Each is linked with VPS35 in more than 17 cancer types. Because this analysis shows association rather than direction, both VPS35-to-partner and partner-to-VPS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of dopamine metabolic process grouped by VPS35-low versus VPS35-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS35→partner) and Y-score (partner→VPS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of dopamine metabolic process →	+0.169	+0.890	<.001	<.001	3	18
BLOOD_Lymphoma	Regulation of locomotion involved in locomotory behavior →	+0.248	+1.077	<.001	<.001	3	16
STOMACH	Positive regulation of dopamine receptor signaling pathway →	+0.211	+0.640	<.001	.002	3	15
PANCREAS	Positive regulation of amine metabolic process →	+0.186	+0.966	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA export from nucleus →	+0.105	+0.763	.003	.003	2	15
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.081	+0.799	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,260 associations by consensus.

Positive regulation of dopamine metabolic process by VPS35 expression — PANCREAS

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