VPS35

Across TCGA cell cohorts, VPS35 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS35-associated genes across cancer lineages are OC90, MS4A10, and EPPIN. Each is linked with VPS35 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS35-to-partner and partner-to-VPS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OC90 grouped by VPS35-low versus VPS35-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS35→partner) and Y-score (partner→VPS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OC90 →	+0.031	+4.867	<.001	.009	3	2
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

OC90 by VPS35 expression — BLOOD_Lymphoma

Explore this box plot interactively →