VPS33A

Across TCGA patient cohorts, VPS33A mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS33A-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and p62 Lck ligand. Each is linked with VPS33A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS33A-to-partner and partner-to-VPS33A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by VPS33A-low versus VPS33A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS33A→partner) and Y-score (partner→VPS33A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.095	-2.000	.025	.030	3	2
UCEC	mTOR_pS2448 →	-0.158	-3.067	.002	<.001	3	2
UCEC	p62 Lck ligand →	+0.371	+2.392	.001	<.001	3	2
UCEC	Shc_pY317 →	-0.190	-2.392	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.310	-1.362	<.001	.037	3	2
UCEC	TFRC →	+0.424	+2.321	.023	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

A-Raf_pS299 by VPS33A expression — UCEC

Explore this box plot interactively →